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The Parthian Conquest of Babylonia and Seleucia (141 BCE)
In 141 BCE, the Parthians, led by King Mithridates I (r. c. 171-132 BCE), achieved a decisive victory by conquering Babylonia and its major Hellenistic city, Seleucia-on-the-Tigris. This marked a pivotal moment in the decline of the Seleucid Empire and the rise of Parthia as the dominant power in the Near East.
The Seleucid Empire, founded by Seleucus I Nicator after the death of Alexander the Great, had long ruled over Mesopotamia. However, by the mid-2nd century BCE, internal strife, dynastic conflicts, and external pressures weakened its hold. The Seleucids faced rebellions in the east, Roman encroachment in the west, and the growing power of the Parthians in Persia.
The Parthians, originally a nomadic Iranian people, had established themselves in the region of Parthia (modern northeastern Iran) and gradually expanded westward. Mithridates I capitalized on Seleucid instability, launching campaigns into Media and Mesopotamia.
In 141 BCE, his forces captured Seleucia, the wealthy and strategically vital Hellenistic city near Babylon. This was a major blow to the Seleucids, as Seleucia was one of their key administrative and economic centers. Shortly after, the Parthians took control of Babylon itself, securing their dominance over southern Mesopotamia.
The Parthian conquest of 141 BCE marked the beginning of their long-lasting empire, which would endure for nearly five centuries. Mesopotamia remained under Parthian control until the rise of the Sassanids in the 3rd century CE.
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